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Adenomatous Polyposis Coli Gene Mutation Alters Proliferation through its β-Catenin-Regulatory Function in Aggressive Fibromatosis (Desmoid Tumor)
Aggressive fibromatosis is a monoclonal proliferation of spindle (fibroblast-like) cells. A subset of lesions contain somatic truncating adenomatous polyposis coli (APC) gene mutations, and all of the lesions contain an elevated β-catenin protein level. A major function of APC is to regulate β-caten...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Investigative Pathology
1998
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1853030/ https://ncbi.nlm.nih.gov/pubmed/9736021 |
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