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Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism.

We determined that mitochondrial respiration reduced cytosolic oxidant stress in vivo and scavenged extramitochondrial superoxide anion (O2-.) in vitro. First, Saccharomyces cerevisiae deficient in both the cytosolic antioxidant cupro-zinc superoxide dismutase (Cu,Zn-SOD) and electron transport (Rho...

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Pubblicato in:J Clin Invest
Autori principali: Guidot, D M, Repine, J E, Kitlowski, A D, Flores, S C, Nelson, S K, Wright, R M, McCord, J M
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1995
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185303/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7635949/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118100
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