Brain Trauma Induces Massive Hippocampal Neuron Death Linked to a Surge in β-Amyloid Levels in Mice Overexpressing Mutant Amyloid Precursor Protein

Although brain trauma is a risk factor for Alzheimer’s disease, no experimental model has been generated to explore this relationship. We developed a model of brain trauma in transgenic mice that overexpress mutant human amyloid precursor protein (PDAPP) leading to the appearance of Alzheimer’s dise...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Smith, Douglas H., Nakamura, Michio, McIntosh, Tracy K., Wang, Jun, Rodríguez, Amarís, Chen, Xiao-Han, Raghupathi, Ramesh, Saatman, Kathryn E., Clemens, James, Schmidt, M. Luise, Lee, Virginia M-Y, Trojanowski, John Q.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 1998
Sujets:
Regular Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853010/
https://ncbi.nlm.nih.gov/pubmed/9736050
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires