Brain Trauma Induces Massive Hippocampal Neuron Death Linked to a Surge in β-Amyloid Levels in Mice Overexpressing Mutant Amyloid Precursor Protein

Although brain trauma is a risk factor for Alzheimer’s disease, no experimental model has been generated to explore this relationship. We developed a model of brain trauma in transgenic mice that overexpress mutant human amyloid precursor protein (PDAPP) leading to the appearance of Alzheimer’s dise...

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Detalhes bibliográficos
Main Authors: Smith, Douglas H., Nakamura, Michio, McIntosh, Tracy K., Wang, Jun, Rodríguez, Amarís, Chen, Xiao-Han, Raghupathi, Ramesh, Saatman, Kathryn E., Clemens, James, Schmidt, M. Luise, Lee, Virginia M-Y, Trojanowski, John Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 1998
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853010/
https://ncbi.nlm.nih.gov/pubmed/9736050
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