Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression.

The present study was aimed to test the role of endothelin-1 (ET-1) as a possible autocrine/paracrine growth factor for cardiac fibroblasts, and to examine its interaction with cardiac natriuretic hormones. Expression of preproET-1 (ppET-1) mRNA by cultured cardiac fibroblasts from neonatal rats was...

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Pubblicato in:	J Clin Invest
Autori principali:	Fujisaki, H, Ito, H, Hirata, Y, Tanaka, M, Hata, M, Lin, M, Adachi, S, Akimoto, H, Marumo, F, Hiroe, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185295/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7635942/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118092
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