Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression.

The present study was aimed to test the role of endothelin-1 (ET-1) as a possible autocrine/paracrine growth factor for cardiac fibroblasts, and to examine its interaction with cardiac natriuretic hormones. Expression of preproET-1 (ppET-1) mRNA by cultured cardiac fibroblasts from neonatal rats was...

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Main Authors: Fujisaki, H, Ito, H, Hirata, Y, Tanaka, M, Hata, M, Lin, M, Adachi, S, Akimoto, H, Marumo, F, Hiroe, M
Formato: Artigo
Idioma:Inglês
Publicado: 1995
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC185295/
https://ncbi.nlm.nih.gov/pubmed/7635942
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