Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.

In extrahepatic tissues lipoprotein lipase (LPL) hydrolyzes triglycerides thereby generating FFA for tissue uptake and metabolism. To study the effects of increased FFA uptake in muscle tissue, transgenic mouse lines were generated with a human LPL minigene driven by the promoter of the muscle creat...

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Detaylı Bibliyografya
Yayımlandı:	J Clin Invest
Asıl Yazarlar:	Levak-Frank, S, Radner, H, Walsh, A, Stollberger, R, Knipping, G, Hoefler, G, Sattler, W, Weinstock, P H, Breslow, J L, Zechner, R
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Clinical Investigation 1995
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7635990/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118145
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.

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