Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.

In extrahepatic tissues lipoprotein lipase (LPL) hydrolyzes triglycerides thereby generating FFA for tissue uptake and metabolism. To study the effects of increased FFA uptake in muscle tissue, transgenic mouse lines were generated with a human LPL minigene driven by the promoter of the muscle creat...

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Pubblicato in:	J Clin Invest
Autori principali:	Levak-Frank, S, Radner, H, Walsh, A, Stollberger, R, Knipping, G, Hoefler, G, Sattler, W, Weinstock, P H, Breslow, J L, Zechner, R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7635990/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118145
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