Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.

In extrahepatic tissues lipoprotein lipase (LPL) hydrolyzes triglycerides thereby generating FFA for tissue uptake and metabolism. To study the effects of increased FFA uptake in muscle tissue, transgenic mouse lines were generated with a human LPL minigene driven by the promoter of the muscle creat...

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Detalhes bibliográficos
Main Authors: Levak-Frank, S, Radner, H, Walsh, A, Stollberger, R, Knipping, G, Hoefler, G, Sattler, W, Weinstock, P H, Breslow, J L, Zechner, R
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC185285/
https://ncbi.nlm.nih.gov/pubmed/7635990
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