Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.

In extrahepatic tissues lipoprotein lipase (LPL) hydrolyzes triglycerides thereby generating FFA for tissue uptake and metabolism. To study the effects of increased FFA uptake in muscle tissue, transgenic mouse lines were generated with a human LPL minigene driven by the promoter of the muscle creat...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Levak-Frank, S, Radner, H, Walsh, A, Stollberger, R, Knipping, G, Hoefler, G, Sattler, W, Weinstock, P H, Breslow, J L, Zechner, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7635990/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118145
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