Distinct C/EBPα motifs regulate lipogenic and gluconeogenic gene expression in vivo

The C/EBPα transcription factor regulates hepatic nitrogen, glucose, lipid and iron metabolism. However, how it is able to independently control these processes is not known. Here, we use mouse knock-in mutagenesis to identify C/EBPα domains that specifically regulate hepatic gluconeogenesis and lip...

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Main Authors: Pedersen, Thomas Å, Bereshchenko, Oxana, Garcia-Silva, Susana, Ermakova, Olga, Kurz, Elke, Mandrup, Susanne, Porse, Bo T, Nerlov, Claus
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852842/
https://ncbi.nlm.nih.gov/pubmed/17290224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601563
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