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XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps

XRCC4 and DNA ligase IV form a complex that is essential for the repair of all double-strand DNA breaks by the nonhomologous DNA end joining pathway in eukaryotes. We find here that human XRCC4:DNA ligase IV can ligate two double-strand DNA ends that have fully incompatible short 3′ overhang configu...

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Detalhes bibliográficos
Main Authors: Gu, Jiafeng, Lu, Haihui, Tippin, Brigette, Shimazaki, Noriko, Goodman, Myron F, Lieber, Michael R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852838/
https://ncbi.nlm.nih.gov/pubmed/17290226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601559
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