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The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
Mdm2 is an E3 ubiquitin ligase that promotes its own ubiquitination and also ubiquitination of the p53 tumour suppressor. In a bacterial two-hybrid screen, using Mdm2 as bait, we identified an Mdm2-interacting peptide that bears sequence similarity to the deubiquitinating enzyme USP2a. We have estab...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1852834/ https://ncbi.nlm.nih.gov/pubmed/17290220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601567 |
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