The p53 isoforms are differentially modified by Mdm2

The discovery that the single p53 gene encodes several different p53 protein isoforms has initiated a flurry of research into the function and regulation of these novel p53 proteins. Full-length p53 protein level is primarily regulated by the E3-ligase Mdm2, which promotes p53 ubiquitination and deg...

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Bibliografiske detaljer
Main Authors: Camus, Suzanne, Menéndez, Sergio, Fernandes, Kenneth, Kua, Nelly, Liu, Geng, Xirodimas, Dimitris P., Lane, David P., Bourdon, Jean-Christophe
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
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Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341231/
https://ncbi.nlm.nih.gov/pubmed/22487680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20119
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