A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin

High-mobility group box 1 (HMGB1) is released extracellularly upon cell necrosis acting as a mediator in tissue injury and inflammation. However, the molecular mechanisms for the proinflammatory effect of HMGB1 are poorly understood. Here, we define a novel function of HMGB1 in promoting Mac-1-depen...

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Autors principals: Orlova, Valeria V, Choi, Eun Young, Xie, Changping, Chavakis, Emmanouil, Bierhaus, Angelika, Ihanus, Eveliina, Ballantyne, Christie M, Gahmberg, Carl G, Bianchi, Marco E, Nawroth, Peter P, Chavakis, Triantafyllos
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852832/
https://ncbi.nlm.nih.gov/pubmed/17268551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601552
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