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Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania
In most eukaryotes, sphingolipids (SLs) are critical membrane components and signaling molecules. However, mutants of the trypanosomatid protozoan Leishmania lacking serine palmitoyltransferase (spt2(−)) and SLs grow well, although they are defective in stationary phase differentiation and virulence...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1852826/ https://ncbi.nlm.nih.gov/pubmed/17290222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601565 |
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