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Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Rα gene during Th1 differentiation

Stat4 is required for Th1 development, although how a transiently activated factor generates heritable patterns of gene expression is still unclear. We examined the regulation of IL-18Rα expression to define a mechanism for Stat4-dependent genetic programming of a Th1-associated gene. Although Stat4...

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Autores principales: Yu, Qing, Thieu, Vivian T, Kaplan, Mark H
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852779/
https://ncbi.nlm.nih.gov/pubmed/17380127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601653
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