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Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Rα gene during Th1 differentiation
Stat4 is required for Th1 development, although how a transiently activated factor generates heritable patterns of gene expression is still unclear. We examined the regulation of IL-18Rα expression to define a mechanism for Stat4-dependent genetic programming of a Th1-associated gene. Although Stat4...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2007
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1852779/ https://ncbi.nlm.nih.gov/pubmed/17380127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601653 |
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