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Stat4 is required for T-bet to promote IL-12-dependent Th1 fate determination

Transcriptional regulatory networks direct the development of specialized cell types. The transcription factors Stat4 and T-bet are required for the development of T helper 1 cells, although the hierarchy of activity by these factors has not been clearly defined. In this report we show that these fa...

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Autori principali: Thieu, Vivian T., Yu, Qing, Chang, Hua-Chen, Yeh, Norman, Nguyen, Evelyn T., Sehra, Sarita, Kaplan, Mark H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768040/
https://ncbi.nlm.nih.gov/pubmed/18993086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.08.017
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