Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation.
The properties of the methyl-directed DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) suggest that it is the enzyme that maintains patterns of methylation in the human genome. Proposals for the enzyme's mechanism of action suggest that 5-methyldeoxycytidine is produced from deoxycytidine via a dih...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1992
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49160/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1584813/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4744 |
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