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Cell-free production of scFv fusion proteins: an efficient approach for personalized lymphoma vaccines

The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represents an ideal tumor-specific antigen for use as a therapeutic vaccine. We have used an Escherichia coli—based, cell-free protein-expression system to produce a vaccine within hours of cloning the Ig genes from a B-c...

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Detalles Bibliográficos
Main Authors: Kanter, Gregory, Yang, Junhao, Voloshin, Alexei, Levy, Shoshana, Swartz, James R., Levy, Ronald
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852255/
https://ncbi.nlm.nih.gov/pubmed/17164345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-030593
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