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Tissue-type plasminogen activator–mediated shedding of astrocytic low-density lipoprotein receptor–related protein increases the permeability of the neurovascular unit

The low-density lipoprotein receptor–related protein (LRP) is a member of the LDL receptor gene family that binds several ligands, including tissue-type plasminogen activator (tPA). tPA is found in blood, where its primary function is as a thrombolytic enzyme, and in the central nervous system where...

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Main Authors: Polavarapu, Rohini, Gongora, Maria Carolina, Yi, Hong, Ranganthan, Sripriya, Lawrence, Daniel A., Strickland, Dudley, Yepes, Manuel
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2007
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852247/
https://ncbi.nlm.nih.gov/pubmed/17170123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-08-043125
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