Tissue-type plasminogen activator and the low-density lipoprotein receptor–related protein induce Akt phosphorylation in the ischemic brain

Tissue-type plasminogen activator (tPA) is found in the intravascular space and in the central nervous system. The low-density lipoprotein receptor–related protein (LRP) is expressed in neurons and in perivascular astrocytes. During cerebral ischemia, tPA induces the shedding of LRP's extracell...

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Main Authors: An, Jie, Zhang, Chen, Polavarapu, Rohini, Zhang, Xiaohui, Zhang, Xiumei, Yepes, Manuel
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556614/
https://ncbi.nlm.nih.gov/pubmed/18628488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-141630
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