The β-tail domain (βTD) regulates physiologic ligand binding to integrin CD11b/CD18

Crystallographic and electron microscopy studies revealed genuflexed (bent) integrins in both unliganded (inactive) and physiologic ligandbound (active) states, suggesting that local conformational changes are sufficient for activation. Herein we have explored the role of local changes in the contac...

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Detalhes bibliográficos
Main Authors: Gupta, Vineet, Gylling, Annette, Alonso, José Luis, Sugimori, Takashi, Ianakiev, Petre, Xiong, Jiang-Ping, Amin Arnaout, M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Phagocytes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852245/
https://ncbi.nlm.nih.gov/pubmed/17170130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-056689
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