T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling

The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely impairs the development and function of B cells but...

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Detalhes bibliográficos
Main Authors: Deane, Jonathan A., Kharas, Michael G., Oak, Jean S., Stiles, Linda N., Luo, Ji, Moore, Travis I., Ji, Hong, Rommel, Christian, Cantley, Lewis C., Lane, Thomas E., Fruman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852227/
https://ncbi.nlm.nih.gov/pubmed/17164340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-038620
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