Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules

TNF family member CD70 is the ligand of CD27, a costimulatory receptor that shapes effector and memory T cell pools. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC)...

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Autors principals: Keller, Anna M., Groothuis, Tom A., Veraar, Elise A. M., Marsman, Marije, de Buy Wenniger, Lucas Maillette, Janssen, Hans, Neefjes, Jacques, Borst, Jannie
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851604/
https://ncbi.nlm.nih.gov/pubmed/17389361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700946104
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