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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are found in organisms from all biological kingdoms. SIR2 itself was originally discovered to influence mating-type control in haploid cells by locus-specific transcriptional silencing. Since then, SIR2 and its homol...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Landry, Joseph, Sutton, Ann, Tafrov, Stefan T., Heller, Ryan C., Stebbins, John, Pillus, Lorraine, Sternglanz, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18515/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811920/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110148297
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