The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are found in organisms from all biological kingdoms. SIR2 itself was originally discovered to influence mating-type control in haploid cells by locus-specific transcriptional silencing. Since then, SIR2 and its homol...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Landry, Joseph, Sutton, Ann, Tafrov, Stefan T., Heller, Ryan C., Stebbins, John, Pillus, Lorraine, Sternglanz, Rolf
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18515/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110148297
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