Induction of Colitis in Mice Deficient of Peyer’s Patches and Mesenteric Lymph Nodes Is Associated with Increased Disease Severity and Formation of Colonic Lymphoid Patches

Inflammatory bowel disease is associated with immune activation in Peyer’s patches and mucosal lymph nodes. The role of these organs in dextran sodium sulfate (DSS)-induced colitis was investigated. We used mice lacking Peyer’s patches and/or lymph nodes because of lymphotoxin-α gene deficiency or t...

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Detalhes bibliográficos
Main Authors: Spahn, Thomas W., Herbst, Hermann, Rennert, Paul D., Lügering, Norbert, Maaser, Christian, Kraft, Mathias, Fontana, Adriano, Weiner, Howard L., Domschke, Wolfram, Kucharzik, Torsten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2002
Assuntos:
Animal Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850913/
https://ncbi.nlm.nih.gov/pubmed/12466141
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