Peripheral Blood and Granuloma CD4(+)CD28(−) T Cells Are a Major Source of Interferon-γ and Tumor Necrosis Factor-α in Wegener’s Granulomatosis

To elucidate whether the fraction of CD28(−) T cells within the CD4(+) T-cell population is a major source of Th1-like and proinflammatory cytokine production driving Wegener’s granulomatosis (WG) granuloma formation, we analyzed the phenotype and functional characteristics of peripheral blood CD4(+...

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Bibliographic Details
Main Authors: Komocsi, Andras, Lamprecht, Peter, Csernok, Elena, Mueller, Antje, Holl-Ulrich, Konstanze, Seitzer, Ulrike, Moosig, Frank, Schnabel, Armin, Gross, Wolfgang Ludwig
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850873/
https://ncbi.nlm.nih.gov/pubmed/12000723
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