Life Span Extension by Reduction in Growth Hormone-Insulin-Like Growth Factor-1 Axis in a Transgenic Rat Model

The longer life span in dwarf mice suggests that a reduction in the growth hormone (GH)-insulin-like growth factor (IGF)-1 axis retards aging and extends the life span in mammals. We tested this hypothesis in a transgenic strain of rats whose GH gene was suppressed by an anti-sense GH transgene. Mal...

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Hauptverfasser: Shimokawa, Isao, Higami, Yoshikazu, Utsuyama, Masanori, Tuchiya, Tomoshi, Komatsu, Toshimitsu, Chiba, Takuya, Yamaza, Haruyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850833/
https://ncbi.nlm.nih.gov/pubmed/12057928
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