Mutation Cluster Region, Association Between Germline and Somatic Mutations and Genotype-Phenotype Correlation in Upper Gastrointestinal Familial Adenomatous Polyposis

Studies of adenomatous polyposis coli (APC) mutations in familial adenomatous polyposis (FAP) have focused on large bowel disease. It has been found that: 1) germline APC mutations around codon 1300 are associated with severe colorectal polyposis; 2) somatic APC mutations in colorectal tumors tend t...

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Main Authors: Groves, Christopher, Lamlum, Hanan, Crabtree, Michael, Williamson, Jill, Taylor, Claire, Bass, Sylvia, Cuthbert-Heavens, Darren, Hodgson, Shirley, Phillips, Robin, Tomlinson, Ian
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2002
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850828/
https://ncbi.nlm.nih.gov/pubmed/12057910
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