Evidence for Early Cytotoxic Aggregates in Transgenic Mice for Human Transthyretin Leu55Pro

Familial amyloidotic polyneuropathy (FAP) is a lethal autosomal dominant disorder characterized by systemic extracellular deposition of transthyretin (TTR) amyloid fibrils. Several groups have generated transgenic mice carrying human TTR Val30Met, the most common mutation in FAP. To study amyloidoge...

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Autores principales: Sousa, Mónica Mendes, Fernandes, Rui, Palha, Joana Almeida, Taboada, Ana, Vieira, Paulo, Saraiva, Maria João
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2002
Materias:
Animal Model
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850789/
https://ncbi.nlm.nih.gov/pubmed/12414539
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