PTEN Mutational Spectra, Expression Levels, and Subcellular Localization in Microsatellite Stable and Unstable Colorectal Cancers

PTEN on 10q23.3 encodes a dual-specificity phosphatase that negatively regulates the phosphoinositol-3-kinase/Akt pathway and mediates cell-cycle arrest and apoptosis. Germline PTEN mutations cause Cowden syndrome and a range of several different hamartoma-tumor syndromes. Hereditary nonpolyposis co...

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Detalhes bibliográficos
Main Authors: Zhou, Xiao-Ping, Loukola, Anu, Salovaara, Reijo, Nystrom-Lahti, Minna, Peltomäki, Päivi, de la Chapelle, Albert, Aaltonen, Lauri A., Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2002
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850747/
https://ncbi.nlm.nih.gov/pubmed/12163369
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