cdk4 Deficiency Inhibits Skin Tumor Development but Does Not Affect Normal Keratinocyte Proliferation

Most human tumors have mutations that result in deregulation of the cdk4/cyclin-Ink4-Rb pathway. Overexpression of D-type cyclins or cdk4 and inactivation of Ink4 inhibitors are common in human tumors. Conversely, lack of cyclin D1 expression results in significant reduction in mouse skin and mammar...

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Bibliographische Detailangaben
Hauptverfasser: Rodriguez-Puebla, Marcelo L., Miliani de Marval, Paula L., LaCava, Margaret, Moons, David S., Kiyokawa, Hiroaki, Conti, Claudio J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2002
Schlagworte:
Short Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850739/
https://ncbi.nlm.nih.gov/pubmed/12163365
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