CpG Island Methylation in Colorectal Adenomas

Methylation of cytosines in CpG islands silences gene expression. CpG island methylator phenotype (CIMP) in colorectal cancers is characterized by abnormal methylation of multiple CpG islands including those in several tumor suppressor genes such as p16, hMLH1, and THBS1. CpG island methylation has...

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Main Authors: Rashid, Asif, Shen, Lanlan, Morris, Jeffrey S., Issa, Jean-Pierre J., Hamilton, Stanley R.
格式: Artigo
語言:Inglês
出版: American Society for Investigative Pathology 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850474/
https://ncbi.nlm.nih.gov/pubmed/11549606
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