CpG Island Methylation in Colorectal Adenomas

Methylation of cytosines in CpG islands silences gene expression. CpG island methylator phenotype (CIMP) in colorectal cancers is characterized by abnormal methylation of multiple CpG islands including those in several tumor suppressor genes such as p16, hMLH1, and THBS1. CpG island methylation has...

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Bibliografiske detaljer
Main Authors: Rashid, Asif, Shen, Lanlan, Morris, Jeffrey S., Issa, Jean-Pierre J., Hamilton, Stanley R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2001
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850474/
https://ncbi.nlm.nih.gov/pubmed/11549606
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