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Inhibition of 5,10-Methenyltetrahydrofolate Synthetase

The interaction of 5-formyltetrahydrofolate analogs with murine methenyltetrahydrofolate synthetase (MTHFS) was investigated using steady-state kinetics, molecular modeling, and site-directed mutagenesis. MTHFS catalyzes the irreversible cyclization of 5-formyltetrahydrofolate to 5,10-methenyltetrah...

詳細記述

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書誌詳細
主要な著者: Field, Martha S., Szebenyi, Doletha M.E., Perry, Cheryll A., Stover, Patrick J.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850231/
https://ncbi.nlm.nih.gov/pubmed/17250800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2006.12.023
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