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Inhibition of 5,10-Methenyltetrahydrofolate Synthetase
The interaction of 5-formyltetrahydrofolate analogs with murine methenyltetrahydrofolate synthetase (MTHFS) was investigated using steady-state kinetics, molecular modeling, and site-directed mutagenesis. MTHFS catalyzes the irreversible cyclization of 5-formyltetrahydrofolate to 5,10-methenyltetrah...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1850231/ https://ncbi.nlm.nih.gov/pubmed/17250800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2006.12.023 |
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