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5,10-Methenyltetrahydrofolate Synthetase Activity is Increased in Tumors and Modifies the Efficacy of Antipurine LY309887

Methenyltetrahydrofolate synthetase (MTHFS) expression enhances folate-dependent de novo purine biosynthesis. In this study, the effect of increased MTHFS expression on the efficacy of the glycinamide ribonucleotide formyltransferase (GARFT) inhibitor LY309887 was investigated in SH-SY5Y neuroblasto...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Arch Biochem Biophys
Main Authors: Field, Martha S., Anguera, Montserrat C., Page, Rodney, Stover, Patrick J.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467886/
https://ncbi.nlm.nih.gov/pubmed/19022216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.11.001
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