Opioids and Efflux Transporters. 1. P-Glycoprotein Substrate Activity of N-Substituted Analogs of Meperidine.

P-Glycoprotein (P-gp) is an efflux transporter which is up-regulated at the blood brain barrier in both morphine and oxycodone tolerant rats. Numerous studies have shown that many clinically employed opioid analgesics are substrates for P-gp, suggesting that up-regulation of P-gp may contribute to t...

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Hlavní autoři: Mercer, Susan L., Cunningham, Christopher W., Hassan, Hazem, Eddington, Natalie D., Coop, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850229/
https://ncbi.nlm.nih.gov/pubmed/17251015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.12.042
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