Llwytho...

Opioids and Efflux Transporters. Part 2: P-Glycoprotein Substrate Activity of 3- and 6-Substituted Morphine Analogs

Continuing our studies investigating opioids with reduced P-glycoprotein (P-gp) substrate activity, a series of known 3- and 6-hydroxy, -methoxy, and -desoxymorphine analogs was synthesized and analyzed for P-gp substrate activity and opioid binding affinity. 6-Desoxymorphine (7) showed high affinit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cunningham, Christopher W., Mercer, Susan L., Hassan, Hazem E., Traynor, John R., Eddington, Natalie D., Coop, Andrew
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401598/
https://ncbi.nlm.nih.gov/pubmed/18311899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701457j
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