Expression of CD44 in Apc and Tcf Mutant Mice Implies Regulation by the WNT Pathway

Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence. This suggests a link with disruption of APC tumor suppressor protein-mediated regulation of β-catenin/Tcf-4 signaling, which is crucial in initiating tumorigenesis. To expl...

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Bibliografiska uppgifter
Huvudupphovsmän: Wielenga, Vera J. M., Smits, Ron, Korinek, Vladimir, Smit, Lia, Kielman, Menno, Fodde, Riccardo, Clevers, Hans, Pals, Steven T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 1999
Ämnen:
Regular Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850011/
https://ncbi.nlm.nih.gov/pubmed/10027409
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