9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication.

A new compound, 9-(3,4-dihydroxybutyl)guanine, has been synthesized and its antiherpes activity determined. 9-(3,4-Dihydroxybutyl)guanine was selectively phosphorylated by herpes simplex virus thymidine kinase and had a high affinity for this enzyme, with an inhibition constant of 1.5 microM. In cel...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Larsson, A, Oberg, B, Alenius, S, Hagberg, C E, Johansson, N G, Lindborg, B, Stening, G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1983
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC184784/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6307131/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.23.5.664
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