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9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication.

A new compound, 9-(3,4-dihydroxybutyl)guanine, has been synthesized and its antiherpes activity determined. 9-(3,4-Dihydroxybutyl)guanine was selectively phosphorylated by herpes simplex virus thymidine kinase and had a high affinity for this enzyme, with an inhibition constant of 1.5 microM. In cel...

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Bibliografiske detaljer
Main Authors: Larsson, A, Oberg, B, Alenius, S, Hagberg, C E, Johansson, N G, Lindborg, B, Stening, G
Format: Artigo
Sprog:Inglês
Udgivet: 1983
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC184784/
https://ncbi.nlm.nih.gov/pubmed/6307131
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