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In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate
BACKGROUND: HIV-1 integrase (IN) is an emerging drug target, as IN strand transfer inhibitors (INSTIs) are proving potent antiretroviral agents in clinical trials. One credible theory sees INSTIs as docking at the cellular (acceptor) DNA-binding site after IN forms a transitional complex with viral...
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| Auteur principal: | |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2007
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1847836/ https://ncbi.nlm.nih.gov/pubmed/17374162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-21 |
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