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CTG Trinucleotide Repeat “Big Jumps”: Large Expansions, Small Mice

Trinucleotide repeat expansions are the genetic cause of numerous human diseases, including fragile X mental retardation, Huntington disease, and myotonic dystrophy type 1. Disease severity and age of onset are critically linked to expansion size. Previous mouse models of repeat instability have not...

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Hlavní autoři: Gomes-Pereira, Mário, Foiry, Laurent, Nicole, Annie, Huguet, Aline, Junien, Claudine, Munnich, Arnold, Gourdon, Geneviève
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847694/
https://ncbi.nlm.nih.gov/pubmed/17411343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030052
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