How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?

Binding degeneracy is thought to constitute a fundamental property of the T-cell antigen receptor (TCR), yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and a peptide (pBM8) bound to the H-2K(bm8) major histocompatibility comple...

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Detalhes bibliográficos
Main Authors: Mazza, Catherine, Auphan-Anezin, Nathalie, Gregoire, Claude, Guimezanes, Annick, Kellenberger, Christine, Roussel, Alain, Kearney, Alice, van der Merwe, P Anton, Schmitt-Verhulst, Anne-Marie, Malissen, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847653/
https://ncbi.nlm.nih.gov/pubmed/17363906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601605
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