Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage

AMP-activated protein kinase (AMPK) responds to impaired cellular energy status by stimulating substrate metabolism for ATP generation. Mutation of the γ2 regulatory subunit of AMPK in humans renders the kinase insensitive to energy status and causes glycogen storage cardiomyopathy via unknown mecha...

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Detalhes bibliográficos
Main Authors: Luptak, Ivan, Shen, Mei, He, Huamei, Hirshman, Michael F., Musi, Nicolas, Goodyear, Laurie J., Yan, Jie, Wakimoto, Hiroko, Morita, Hiroyuki, Arad, Michael, Seidman, Christine E., Seidman, J.G., Ingwall, Joanne S., Balschi, James A., Tian, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847536/
https://ncbi.nlm.nih.gov/pubmed/17431505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30658
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