Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage

AMP-activated protein kinase (AMPK) responds to impaired cellular energy status by stimulating substrate metabolism for ATP generation. Mutation of the γ2 regulatory subunit of AMPK in humans renders the kinase insensitive to energy status and causes glycogen storage cardiomyopathy via unknown mecha...

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Hlavní autoři: Luptak, Ivan, Shen, Mei, He, Huamei, Hirshman, Michael F., Musi, Nicolas, Goodyear, Laurie J., Yan, Jie, Wakimoto, Hiroko, Morita, Hiroyuki, Arad, Michael, Seidman, Christine E., Seidman, J.G., Ingwall, Joanne S., Balschi, James A., Tian, Rong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2007
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847536/
https://ncbi.nlm.nih.gov/pubmed/17431505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30658
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