Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice

OBJECTIVE—We determined whether muscle AMP-activated protein kinase (AMPK) has a role in the development of insulin resistance. RESEARCH DESIGN AND METHODS—Muscle-specific transgenic mice expressing an inactive form of the AMPK α2 catalytic subunit (α2i TG) and their wild-type littermates were fed e...

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Autores principales: Fujii, Nobuharu, Ho, Richard C., Manabe, Yasuko, Jessen, Niels, Toyoda, Taro, Holland, William L., Summers, Scott A., Hirshman, Michael F., Goodyear, Laurie J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2008
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570392/
https://ncbi.nlm.nih.gov/pubmed/18728234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1187
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