Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E(2 )from human articular chondrocytes

BACKGROUND: Sphingosine-1-phosphate (S1P), a downstream metabolite of ceramide, induces various bioactivities via two distinct pathways: as an intracellular second messenger or through receptor activation. The receptor for S1P (S1PR) is the family of Endothelial differentiation, sphingolipid G-prote...

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Main Authors: Masuko, Kayo, Murata, Minako, Nakamura, Hiroshi, Yudoh, Kazuo, Nishioka, Kusuki, Kato, Tomohiro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847513/
https://ncbi.nlm.nih.gov/pubmed/17374154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-8-29
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