Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies.

Aminoglycoside antibiotics induce an early and characteristic lysosomal phospholipidosis in cultured fibroblasts and in kidney tubular cells. We have recently demonstrated an inhibition of lysosomal phospholipases A1 and A2 by gentamicin and amikacin in vitro. In vivo, gentamicin decreases the activ...

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Bibliografiske detaljer
Main Authors: Carlier, M B, Laurent, G, Claes, P J, Vanderhaeghe, H J, Tulkens, P M
Format: Artigo
Sprog:Inglês
Udgivet: 1983
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC184667/
https://ncbi.nlm.nih.gov/pubmed/6847172
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